A Meta-Analysis on GeneXpert Using Stool Samples in Diagnosing Pediatric Pulmonary Tuberculosis
Othella Mary Ann S. Cacayorin, M.D.

Objectives: To find an alternative specimen for GeneXpert assay in the diagnosis of pediatric pulmonary tuberculosis (PTB). To determine the sensitivity and specificity of using stool samples as an alternative to sputum for GeneXpert assay.

Methods: A systematic search was done using an electronic database (e.g. Pubmed). Using the keywords “GeneXpert”, “tuberculosis”, “Stool samples”. QUADAS-2 checklist was used in assessing the studies gathered. Revman 5.3 was used to determine the sensitivity and specificity of the study included in this meta-analysis.

Results: A total of 185 stool samples were included in this review, which showed a median sensitivity of 77% (IQR 0.63-0.87) and median specificity of 98% (IQR 0.95-1.0).

Conclusion: Despite the heterogeneous sensitivity, GeneXpert has a high specificity, which enabled rapid diagnosis of pulmonary tuberculosis promoting timely initiation of appropriate therapy.